ATIA: A link between inflammation and hypoxia
Source:
Time: 2011-06-28
On issue 5, volume 42 of the prestigious journal Molecular Cell, Prof. Anning Lin published a preview entitled ATIA: A link between inflammation and hypoxia, which introduces and comments on an article entitled A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2 by Choksi et al. In this preview, Prof. Lin summarizes the background and major findings of Choksi et al., pointing out that these findings uncover a link between inflammation and hypoxia, shed light on the NF-κB-independent mechanism of apoptosis inhibition, and may provide novel therapeutic targets for prevention and treatment of certain types of solid tumors. Prof. Lin also raises several interesting questions that merit further investigation in the future.
Schematic Illustration of ATIA Serving as a Link between Inflammation and Hypoxia
The ATIA-TRX2 axis inhibits apoptosis induced by both TNFα and low O2 through elimination of excessive ROS on mitochondria. Thus, ATIA may be a key regulator in solid tumors like human glioblastoma, which needs to survive and grow under hypoxia conditions and withstands TNFα cytotoxicity
Appendix：
