Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Zhen Lin, Bowen Rong, Ruitu Lyu, Yuxuan Zheng, Yao Chen, Junyi Yan, Meixia Wu, Xiaogang Gao, Fuchou Tang, Fei Lan, Ming-Han Tong,SETD1B-mediated broad H3K4me3 controls proper temporal patterns of gene expression critical for spermatid development,Cell Res.2025 Mar 4.
Si-Kun Guo, Jinlong Suo, Youkui Huang, Xubin Yin, Jinghui Wang, Ling Li, Shaokun Sun, Weiguo Zou, Ling-Ling Chen,Therapeutic circRNA aptamer alleviates PKR-associated osteoarthritis,Sci Bull (Beijing).2025 Feb 20.
Yifan Chen, Yifei Zhou, Yaqing Bai, Kaiwen Jia, Hao Zhang, Qingxia Chen, Mengjiao Song, Yumin Dai, Jiantao Shi, Zhengjun Chen, Xiumin Yan, Yidong Shen,Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier,Neuron.2025 Feb 19.
Libo Luo, Rui Xia, Shiqi Mao, Qian Liu, He Du, Tao Jiang, Shuo Yang, Yan Wang, Wei Li, Fei Zhou, Jia Yu, Guanghui Gao, Xuefei Li, Chao Zhao, Lei Cheng, Jingyun Shi, Xiaoxia Chen, Caicun Zhou, Luonan Chen, Shengxiang Ren, Fengying Wu,Differential expression of the MYC-Notch axis drives divergent responses to the front-line therapy in central and peripheral extensive-stage small-cell lung cancer,MedComm.2025 Feb 18.
Xinzhe Tang, Zetao Hu, Jian Ding, Meixia Wu, Pin Guan, Yawei Song, Yue Yin, Wei Wu, Jinbiao Ma, Ying Huang & Ming-Han Tong,In vitro reconstitution of meiotic DNA double-strand-break formation,Nature.2025 Feb 19.
Xiao Tao, Si-Nan Zhai, Chu-Xiao Liu, Youkui Huang, Jia Wei, Yi-Lin Guo, Xiao-Qi Liu, Xiang Li, Li Yang, Ling-Ling Chen,Degradation of circular RNA by the ribonuclease DIS3,Mol Cell.2025 Feb 17.
Xiaosheng Bai, Xinyu Bao, Chuanchao Zhang, Qianqian Shi, Luonan Chen,SpaDCN: Deciphering Spatial Functional Landscape from Spatially Resolved Transcriptomics by Aligning Cell-Cell Communications,Small Methods.2025 Feb 17.
Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang,MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury,Cell Discov.2025 Feb 18.
Meng Yan, Xiaoyu Merlin Zhang, Zhenhua Yang, Miao Jia, Rongyu Liao, Jinsong Li,Visualization of chromosomal reorganization induced by heterologous fusions in the mammalian nucleus,Nat Commun.2025 Feb 10.
Ximeng Han, Yi Li, Enci Wang, Huan Zhu, Xiuzhen Huang, Wenjuan Pu, Mingjun Zhang, Kuo Liu, Huan Zhao, Zixin Liu, Yufei Zhao, Linghong Shen, Yan Li, Xiao Yang, Qing-Dong Wang, Xin Ma, Ruling Shen, Kathy Lui, Lixin Wang, Ben He, Bin Zhou,Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics,Circulation.2025 Feb 10.
Xiaojing Gao, Yuanyuan Yin, Yiqian Chen, Ling Lu, Jian Zhao, Xu Lin, Jiarui Wu, Qingrun Li, Rong Zeng,Uncovering dark mass in population proteomics: Pan-analysis of single amino acid polymorphism relevant to cognition and aging,Cell Genom.2025 Jan 26.
Shan-Shan Wang, Jia Yuan, Xinyu Thomas Tang, Xiujuan Yin, Ke Fang, Lin Veronica Chen, Zhenggang Ren, Bo O Zhou,Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis,J Exp Med.2025 Jan 31.
Yulin Chao, Zixuan Zhou, Hao Xia, Chuanhui Yang, Tingting Li , Yi-Quan Tang, Yilai Shu, Qian Ba, Jiaxu Hong, Dianfan Li, Qianhui Qu,Transport and inhibition mechanism for human TauT-mediated taurine uptake,Cell Res.2025 Jan 21.
Hao Wu, Chu-Xiao Liu, Ling-Ling Chen,Beyond housekeeping: a new role of snoRNA in nascent protein secretion,Cell Res.2025 Jan 20.
Yongjian Ma, Meng Yan, Zhenfei Xie, Hongling Zhang, Zhoujie Li, Yuanyuan Li, Suming Yang, Meiling Zhang, Wen Li & Jinsong Li,Generation of live mice from haploid ESCs with germline-DMR deletions or switch,Cell Discov.2025 Jan 21.
Qi Xiong, Zhini Zhu, Tingting Li, Xiaotian Li, Zixuan Zhou, Yulin Chao, Chuanhui Yang, Suihan Feng, Qianhui Qu & Dianfan Li,Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling,Nat Struct Mol Biol.2025 Jan 17.
Feifei Zhang, Ryan D. Chow, Emily He, Chuanpeng Dong, Shan Xin, Daniyal Mirza, Yanzhi Feng, Xiaolong Tian, Nipun Verma, Medha Majety, Yueqi Zhang, Guangchuan Wang & Sidi Chen,Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy,Nat Biotechnol.2025 Jan 16.
Yanpu Wu, Xinyan Zhang, Liang Sun, Qingqing Wu, Xiaoping Liu, Yueyi Deng, Zhenzhen Lu, Zhongxia Li, Chaoming Deng, Ruikun He, Luyun Zhang, Rong Zeng, Xuguang Zhang, Luonan Chen, Xu Lin,Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study,Natl Sci Rev.2024 Nov 26.
Pengyu Fan, Xue-Ying Shang, Aixia Song, Shuo Chen, Run-Yuan Mao, Jingchuan Ma, Jiwei Chen, Zhenning Wang, Hai Zheng, Bolin Tao, Lei Hong, Jiaxian Liu, Wei Xu, Wei Jiang, Hongjie Shen, Qi Zhang, Huijuan Yang, Xiao-Ming Meng, Fei Lan, Jingdong Cheng, Congling Xu, Peng Zhang, Hai Jiang & Fei Xavier Chen,Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition,Nat Chem Biol.2025 Jan 14.
Qian Ren, Wenhui Xing, Bo Jiang, Heng Feng, Xuye Hu, Jinlong Suo, Lijun Wang & Weiguo Zou,Tenascin-C promotes bone regeneration via inflammatory macrophages,Cell Death Differ.2025 Jan 10.

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