Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Jinlong Suo, Duo Wang, Jinghui Wang, Xubin Yin, Xuye Hu, Rui Shao, Shuqin Chen, Shaokun Sun, Jingyi Feng, Lijun Wang, Heng Feng, Zhengda Li, Wulei Hou, Lei Zhang, Yong Chen, Xianyou Zheng, Zuoyun Wang, Weiguo Zou,Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model,Nat Commun.2025 Oct 22.
Weiyun Li, Miao Jin, Hongye Li, Ruiyue Zhong, Zhaoheng Lin, Miao Shen, Hongyan Wang,Amino acid and cholesterol metabolism in innate immunity,Mol Cell.2025 Oct 16.
Jiaoyang Li, Zhizhou Xia, Bo Jiao, Zhitong Li, Donghe Li, Pengfei Xu, Yi Huang, Jiawei Nie, Yuqing Dan, Xu Huang, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Shiyu Ji, Mofang Liu, Ping Liu, Ruibao Ren,Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice,Sci Adv.2025 Oct 17.
Zhenqian Zhang, Hengwei Jin, Zhicong Liu, Mengyang Shi, Mingjun Zhang, Wenjuan Pu, Jie Li, Xuekun Li, Daqing Ma, Qiang Shu, Bin Zhou,Pleural cavity macrophages promote lung tumor establishment through tissue invasion,Protein Cell.2025 Oct 16.
Hua Li, Li Meng, Chun Chu, Changting Li, Haochen Yang, Kexin Cao, Yiming Zhu, Xue Gao, Chengsong Yan, Omer Dushek, Haopeng Wang, Xiaoshan Shi, Chenqi Xu,Lipid-regulated phosphorylation hierarchy of the T cell receptor tyrosine motifs,Mol Cell.2025 Oct 2.
Xinyan Zhang, Luonan Chen,Quantifying interventional causality by knockoff operation,Adv Sci.2025 Oct 3.
Hui Chen, Zhicong Liu, Qiang Shu, Bin Zhou,Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications,Adv Sci.2025 Sep 29.
Jinlong Suo, Ling Li, Wuyuan Tan, Xubin Yin, Jinghui Wang, Rui Shao, Shaokun Sun, Si-Kun Guo, Jingyi Feng, Bao-Qing Gao, Ying Wang, Meng-Yuan Wei, Lijun Wang, Heng Feng, Xiang Gao, Ping Hu, Xianyou Zheng, Ling-Ling Chen, Guanghua Lei, Youkui Huang, Weiguo Zou,Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice,Nat Commun.2025 Sep 26.
Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu, Ding Song, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huanwei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng, Hai Jiang,A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2,Nat Biotechnol.2025 Sep 10.
Xiao-Peng Han, Ming Rao, Yu Chang, Jun-Yan Zhu, Jun Cheng, Yu-Ting Li, Wu Qiong, Si-Chao Ye, Qiurong Zhang, Shao-Qing Zhang, Ling-Ling Chen, Fajian Hou, Jin Zhong, Jiaquan Liu,ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly,Cell Res.2025 Sep 19.
Rui Gao, Chang Xu, Chen Liu, Zhenyan Zhu, Min Wang, Xueyan Wei, Peng Ning, Wei Zhang, Yingze Li, Yajuan Zhang, Junwu Shen, Yifan Tong, Feng Tao, Xiaolei Chen, Xiaoyi Jiang, Huan Ren, Cheng Lv, Gustavo R Plaza, Jason Miska, Haiming Fan, Xiaoqing Zhang, Yichao Tang, Yalei Dai, Weiwei Yang, Bin He, Yu Cheng,An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano-Immunotherapy,Adv Mater.2025 Sep 13.
Jun Lu, Minjuan Hu, Yikai Zhao, Tianqing Chu, Wei Zhang, Yijia Zhou, Xinlei Cai, Jun Wu, Liang Hu, Chunlei Shi, Liwen Xiong, Aiqin Gu, Huimin Wang, Yanwei Zhang, Yuqing Lou, Runbo Zhong, Zhiqiang Gao, Hongyu Liu, Chao Zhou, Yingli Wu, Liang Zhu, Hua Zhong, Hongbin Ji, Baohui Han,Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer,Signal Transduct Target Ther.2025 Sep 12.
Zhengxu Ren, Chenqi Xu,Touch of youth: Mechanosensing expands stem-like CAR-T cells,Immunity.2025 Sep 9.
Jiangshan Cong, Qing Li, Yangyang Li, Minghao Li, Yan Shi, Peiran Hu, Xidi Yin, Qianyun Zhang, Jianzhong Sheng, Jinsong Li, Guolian Ding, Yu Zhang, Hefeng Huang,Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference,Cell Discov.2025 Sep 9.
Yawei Song, Zilv Mei, Qijie Zheng, Qingqing Yuan, Yu Liang, Jiaqi Gao, Lang Zhou, Shuheng Wu, Wei Wu,Benchmarking Ploidy Estimation Methods for Bulk and Single-Cell Whole Genome Sequencing,Adv Sci (Weinh).2025 Sep 8.
Kaile Wang, Rui Ye, Shanshan Bai, Zhenna Xiao, Lei Yang, Jianzhuo Li, Chenling Tang, Emi Sei, Jinyu Peng, Anna K Casasent, Steven H Lin, Chandandeep Nagi, Alastair M Thompson, Savitri Krishnamurthy, Nicholas E Navin,Coalescing single-cell genomes and transcriptomes to decode breast cancer progression,Cell.2025 Aug 26.
Maoying Han, Zhicong Liu, Lei Liu, Zhixin Kang, Xiuzhen Huang, Nicola Smart, Xuekun Li, Qiang Shu, Bin Zhou,Spatio-Temporal Proliferative Heterogeneity of Intra-Organ Endothelial Cells,Circ Res.2025 Aug 15.
Runyang Feng, Zheyan Fang, Shuang Zhao, You-en Zhang, Na Wu, Zhenyang Guo, Xin Zhong, Bixuan Jiang, Hongfei Xu, Hangnan Hong, Zhentao Zhang, Mukaddas Abdurahman, Xueting Yu, Jilong Geng, Xiansu Nie, Supuya Abuduwahapi, Dong Huang, Gang Zhao, Wenbin Zhang, Hao Lu, Li Shen, Xin Zhao, Zhaoyang Chen, Junjie Guo, Hongchao Zheng, Yue He, Sanwu Wu, Jiayin Peng, Jiawen Song, Xiao Wang, Haomin Li, Yuli Huang, Shengying Qin, Haojie Lu, Xiangdong Wang, Jianguo Zhao, Lei Huang, Yun Zhao, Peng Li, Junbo Ge, Hua Li,SIRT6 Lysine-Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE-Cadherin Pathway Regulating Vascular Endothelial Barrier,Adv Sci.2025 Aug 14.
Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu, Yurun Lu, Yehan Zhang, Shiwei Guo, Juan He, Yikai Li, Yi Zhang, Xiaohan Shi, Yuanxiang Miao, Chaoliang Zhong, Yiqin Zhu, Yi Ju, Yuejia Liu, Maoyuan Sun, Yong Wang, Luonan Chen, Hu Zhou, Gang Jin, Dong Gao,A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy,Cell Stem Cell.2025 Aug 13.
Yuzhu Zhang, Changping Yin, Yimin Wang, Kunming Yan, Bo Zhao, Xin Hu, Youzhong Wan, Hong Cheng, Jing Huang,A common structural mechanism for RNA recognition by the SF3B complex in mRNA splicing and export,Nucleic Acids Res.2025 Aug 11.

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