Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Xiuxiu Liu, Wendong Weng, Zhen He, Kuo Liu, Maoying Han, Wenjuan Pu, Bin Zhou,Highly regional generation and heterogeneous differentiation of basal cells in mouse trachea,Cell Discov.2026 Mar 30.
Zhengtao Zhang, Hong Li, Lingli Chen, Tao Lu, Xinyi Shentu, Yuanhua Liu, Zhixuan Tang, Shuyi Ji, Zhixin Qiu, Yining Zou, Hong Wen, Jing Han, Zhengzeng Jiang, Jie Fan, Xinbo Gao, Dianfan Li, Agavni Mesropian, Roser Pinyol, Josep M Llovet, Hui Dong, Yuan Ji, Lijian Hui,Molecular insights into early malignant transition of hepatocellular carcinoma,Cancer Cell.2026 Mar 26.
Xinzhe Tang, Ming-Han Tong,Mechanism and regulation of meiotic double-strand break formation in mammals,Trends Biochem Sci.2026 Mar 17.
Xinxin Rao, Jingwen Wang, Zhibin Qiao, Lei Hong, Mengxue Qiao, Liangwei Ni, Aixia Song, Yun Deng, Xu Zhao, Jin Meng, Xingxing Chen, Yifan Zhou, Jingyan Xue, Yayun Chi, Xinrui Wang, Zhaowei Yu, Qianqian Chen, Congling Xu, Shuang Tang, Jing Hu, Midie Xu, Wei Xu, Zhen Zhang, Yong Zhang, Yanhui Xu, Yi-Zhou Jiang, Jiong Wu, Minhong Shen, Xiaomao Guo, Xiaoli Yu, Fei Xavier Chen,Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis,Cell Stem Cell.2026 Mar 16.
Weihao Sun, Hongyu Liu, Pengcheng Pang, Guanyu Ren, Zhuanghui Feng, Lei Wang, Shuguang Piao, Miaoxia He, Haoyu Shen, Jinsong Li, Xin Li, Chenghua Yang, Linhui Wang, Zhiyong Liu,Integrated single-nucleus transcriptomic and chromatin accessibility analysis reveals key molecular basis of human testicular aging,J Mol Cell Biol.2026 Mar 9.
Xinyi Han, Lingwei Ma, Jiahui Dai, Dong Gao, Wei Wan,Organoids revolutionizing precancer research,J Adv Res.2026 Mar 6.
Yi Ni Luo, Yazi Deng, Yu Liang, Wei Wu, Wei Wu, Lu Wang,A de novo H3.2K9me2 deposition pathway establishes heterochromatin for suppressing transposon mobilization during fly somatic development,Nucleic Acids Res.2026 Feb 24.
Youkui Huang, Yao-Qi Chen, Si-Yu Lou, Xiang Gao, Yu-Xin Liu, Yu-Lu Zhang, Fang Nan, Ling-Ling Chen, Li Yang,IRES-cargo interplay structurally modulates circular RNA translation,Cell Res.2026 Feb 26.
Huanhuan Feng, Zhixue Li, Hongdao Zhang, Yuli Zheng, Beiying Xu, Yao Zhang, Lin Zou, Ligang Wu,Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells,Nucleic Acids Res.2026 Feb 5.
Yuanhao Wang, Yuhan Wang, Wenjie Yuan, Mingyu Fan, Xiaojing Wang, Anhui Wang, Yanling Bao, Yajing Zhang, Jia Chi Tan, Jianglai Wang, Junshuang Liu, Tianqi Huang, Zixuan Han, Biling Pei, Lijuan Chen, Zhengxu Ren, Xueqing Wang, Lanxin Hu, Siqi Wu, Mengke Pang, Sifan Wang, Zihuan Yang, Jiaze Li, Delian Huang, Shuai Shao, Huairui Yuan, Ling Wu, Yinnian Feng, Penghui Zhou, Guohui Li, Bo Sun, Chenqi Xu, Nicholas R J Gascoigne, Xiang Zhao,Tuning the sensitivity of mechanosensory receptors through histidine scanning,Cell.2026 Feb 18.
Huan Zhao, Hui Chen, Zhixin Kang, Xiuzhen Huang, Jingting Zhu, Zixin Liu, Xiuxiu Liu, Ximeng Han, Jie Lu, Bin Zhou,Genetic recording of pancreatic beta cell proliferation,Proc Natl Acad Sci U.S.A.2026 Feb 17.
Yinghua Wang, Weiwei Hu, Rui Xia, Xianfa Yang, Yange Gu, Zihan Ning, Tiange Yang, Chune Yu, Lulu Zhang, Dun Li, Yitian Jin, Jianhua Li, Feifei Zhang, Yaochen Xu, Chenqi Xu, Zhengxin Wang, Naihe Jing, Luonan Chen, Guangchuan Wang,CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response,Cell.2026 Feb 11.
Liucheng Li, Jianwei You, Zi-Qing Chai, Xueshan Li, Xinlei Cai, Lin Wang, Fang Yang, Lingzhi Zhu, Wen Mi, Xinyi Xia, Haohang Yan, Fei Li, Juan Wang, Tong-Jin Zhao, Ligong Chen, Hongbin Ji, Pingyu Liu, Xiao-Long Zhou, Li Chen & Fuming Li,SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth,Nat Metab.2026 Feb 6.
Dongyin He, Haoran Hu, Kai Xiao, Yuhang Zhang, Yongbing Cheng, Shaozhuo Jiao, Yimei Hao, Yuanyuan Cai, Ziqun Liu, Xinran Yan, Qinsheng Chen, Xiyan Mu, Qi Wang, Shan Peng, Guoqin Sang, Xiaoling Zhi, Yanxia Chang, Qing Ye, Yuyao Yang, Meixia Che, Shengsong Huang, Hongqian Guo, Luonan Chen, Huiru Tang, Xuefeng Qiu, Zhenfei Li,Analysis of the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins using snFLARE-seq and mxFRIZNGRND,Nat Commun.2026 Feb 7.
Wen Xiao, Yuli Zheng, Hongdao Zhang, Beiying Xu, Ruiwen Zhang, Ligang Wu,An absolute quantification atlas of small non-coding RNAs across diverse mammalian tissues and cell lines,Nat Commun.2026 Feb 3.
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang,Single-Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems,Adv Sci.2026 Feb 3.
Yingze Li, Mengge Zheng, Zhenyan Zhu, Yajuan Zhang, Peng Ning, Haotian Chen, Rui Gao, Chang Xu, Xueyan Wei, Yali Liu, Yingying Wang, Ruimei Zhou, Yuan Li, Zhenguang Li, Cheng Lv, Chen Liu, Junfang Xu, Zihan Guo, Zhixiang Hu 1 2 3 4, Lan Fang 9, Ke Wei 10, Mengying Feng 10, Changshi Zhou 11 12, Yunlang She 1, Weiyan Sun 1, Erzhen Chen, Gustavo R Plaza, Bin He, Jason Miska, Weiwei Yang, Yichao Tang, Haipeng Liu, Chang Chen, Yu Cheng,Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity,Cell Res.2026 Feb 3.
Man Jiang, Yu Li, Yiao Jiang, Runze Wang, Jiayin Peng, Yuang Wang, Zhen Qu, Yi Chang, Zhao Zhang, Yun Zhao,Hilnc- mediated UCP1 translation repression contributes to thermogenesis and energy expenditure,Theranostics.2026 Jan 1.
Xuefang Dong, Fangfang Xiong, Guangzhu Du, Yunfei Yang, Cheng Chen, Yun Cui, Xinlian Ding, Xiuling Li, Yidong Shen, Xinmiao Liang,A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration,Nat Commun.2026 Jan 28.
Jia-Xin Zhou, Zhen-Yu Shao, Lin Zhang, Jian-Nan Guo, Meng Wang, Qin Xu, Yi-Qin Wang, Qing Xu, Dan Zhou, Sheng-Xiang Ren, Yan-Hao Yu, Zhi-Hao Lu, Guo-Zheng Pang, Yao Cao, Yi-Lin Liu, Bin Zhou, Hong-Bin Ji, Yi-Han Chen, Hai-Ping Wu, Guo-Liang Xu, Liang Zhang & Ya-Rui Du,Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers,Nat Chem Biol.2026 Jan 22.

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