Ph.D., Professor
Professor of Biochemistry and Molecular Biology,
State Key Laboratory of Molecular Biology,
Shanghai Institute of Biochemistry and Cell Biology,
Center for Excellence in Molecular Cell Science,
Chinese Academy of Sciences,
320 Yue-yang Road, Shanghai 200031, China.
Tel: 86-021-54921121; FAX: 86-021-54921011.
Protein Aggregation, Inclusion, Sequestration, Interaction, Phase Transition, Proteostasis, Proteinopathy;
Cellular Homeostasis, Molecular Chaperone, Ubiquitin-Proteasome, Protein Degradation, RNA-Binding Protein, Ribostasis, Loss-of-Function, Cytotoxicity, Neurodegeneration;
Cellular Biochemistry, Biochemical Techniques, Biophysical Techniques, Nuclear Magnetic Resonance,Fluorescence,Immunofluorescence Microscopy.
The hallmark of some neurodegenerative diseases is the aggregation of abnormal proteins and formation of inclusion bodies in neural cells. The research group focuses on the mechanism of protein misfolding, amyloidogenic aggregation and sequestration, and phase transition of the cellular related proteins. Based on biochemical, structural and cellular information, we are trying to understand the proteinopathies of polyQ proteins and RNA-binding proteins associated with neurodegenerative diseases. The research areas are:
(1) Mechanism of protein misfolding, aggregation and inclusion formation, phase transition, and their cellular effects;
(2) Sequestration of cellular essential proteins by the protein aggregates and inclusions;
(3) Proteostasis network of the amyloidogenic proteins associated with neurodegenerative diseases;
(4) Structural basis for and functional annotation of the molecular recognition involved in proteostasis network and protein quality control.
1987, B.S., Department of Biology, Fudan University;
1990, M.S., Department of Chemistry, Fudan University;
1993, Ph. D., Shanghai Institute of Biochemistry, Chinese Academy of Sciences;
1993-1994, Assistant Professor, Shanghai Institute of Biochemistry, Chinese Academy of Sciences;
1994-1996, Postdoctoral, Department of Biochemistry, the Hong Kong University of Science & Technology, Hong Kong;
1996-2000, Associate Professor, Shanghai Institute of Biochemistry, Chinese Academy of Sciences;
2000, Visiting Scholar, Laboratory of NMR Structural Biology, Department of Biochemistry, University of Connecticut Health Center, USA;
2001-2019, Professor, Institute of Biochemistry & Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2002-2003, Visiting Scholar, the Hong Kong University of Science & Technology, Hong Kong;
2004, Visiting Scholar, Department of Molecular and Experimental Medicine, The Scripps Research Institute, USA;
2020-present, Professor, Shanghai Institute of Biochemistry & Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences.
Academic Activities
Council Member of the Chinese Molecular Biophysics Society (2011—)
Council Member of the Shanghai Society of Biochemistry and Molecular Biology (2011—2018)
Council Member of the Chinese Protein Society (2006 —2015);
Council Member of the Chinese Society of Biochemistry and Molecular Biology (2005—2014);
Editorial Board Member of Protein & Peptide Letters (2005—);
Editorial Board Member of Acta Biochem Biophys Sinica (2007—);
Editorial Board Member of Scientific Reports (2015—).