Home  /  Faculty  /  Principal Investigators
  • SHEN Yidong
  • Ph.D., Professor
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.
  • E-mail：yidong.shen@@sibcb.ac.cn
    Selected Publications
    1. Wang, X., Jiang, Q., Song, Y., He, Z., Zhang, H., Song, M., Zhang, X., Dai, Y., Karalay, O., Dieterich, C., Antebi, A., Wu, L., Han, J & Shen, Y. (2022). Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans. EMBO J, 41:e109633.
    2. Zhang, Y., Zhang, X., Dai, Y., Song, M., Zhou, Y., Zhou, J., Yan, X & Shen, Y. (2021). The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing. Nat Commun, 12(1):1789.
    3. Zhou, Y., Wang, X., Song, M., He, Z., Cui, G., Peng, G., Dieterich, C., Antebi, A., Jing, N and Shen, Y. (2019). A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nat Commun, 10(1):4827.
    4. Xu, Y., He, Z., Song, M., Zhou, Y & Shen, Y. (2019). A microRNA switch controls dietary restrictioninduced longevity through Wnt signaling. EMBO R, e46888.
    5. Shen, Y., Wollam, J., Magner, D., Karalay, O., and Antebi, A. (2012). A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. Science 338, 1472-1476.
    6. Cao, J.*, Shen, Y.*, Zhu, L., Xu, Y., Zhou, Y., Wu, Z., Li, Y., Yan, X., and Zhu, X. (2012). miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol 14, 697-706.
    7. Shen, Y.*, Li, N.*, Wu, S., Zhou, Y., Shan, Y., Zhang, Q., Ding, C., Yuan, Q., Zhao, F., Zeng, R., et al. (2008). Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 14, 342-353.
    8. Magner, D.B., Wollam, J., Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H., and Antebi, A. (2013). The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans. Cell Metab 18, 212-224.
    9. Heestand, B.N., Shen, Y., Liu, W., Magner, D.B., Storm, N., Meharg, C., Haberman, B., Antebi, A. (2013). Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans. PLoS Genet 9(7): e1003651.
    10. Wollam, J., Magner, D.B., Magomedova, L., Rass, E., Shen, Y., Rottiers, V., Habermann, B., Cummins, C.L., and Antebi, A. (2012). A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol 10, e1001305.
    11. Wollam, J., Magomedova, L., Magner, D.B., Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., and Antebi, A. (2011). The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell 10, 879-884.
    12. Yan, X., Shen, Y., and Zhu, X. (2010). Live show of Rho GTPases in cell migration. J Mol Cell Biol 2, 68-69.
    13. Zhang, Q., Wang, F., Cao, J., Shen, Y., Huang, Q., Bao, L., and Zhu, X. (2009). Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic 10, 1337-1349.
    14. Yan, X., Li, F., Liang, Y., Shen, Y., Zhao, X., Huang, Q., and Zhu, X. (2003). Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol 23, 1239-1250.
Copyright 2017-2025　Shanghai Institute of Biochemistry and Cell Biology, CAS.　All rights reserved
Registration Number : Shanghai ICP : 2021025838　 Beijing ICP : 05002857-1
Address:320 Yue Yang Road, Shanghai 200031, P.R. China　Post:200031　Fax:021-54921011　Email:sibcb@sibcb.ac.cn