• DAI Haiqiang
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  • E-mail:haiqiang.dai@@sibcb.ac.cn
    Selected Publications
    1. Jiayang Li, Hai-Qiang Dai*. Mesoscale sequence feature modulates AID activity in antibody diversification. Acta Biochimica et Biophysica Sinica. (2023). https://doi.org/10.3724/abbs.2023145.
    2. Zhuoyi Liang, Lijuan Zhao, Adam Yongxin Ye, Sherry G Lin, Yiwen Zhang, Chunguang Guo, Hai-Qiang Dai, Zhaoqing Ba, Frederick W. Alt. Contribution of the IGCR1 regulatory element and the 3′Igh CTCF-binding elements to regulation of Igh V(D)J recombination. Proceedings of the National Academy of Sciences. (2023). 120 (26), e2306564120.
    3. Sai Luo, Jun Zhang, Alex JB Kreutzberger, Amanda Eaton, Robert J Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S Munir Alam, David C Montefiori, Kevin O Saunders, Ming Tian, Hidde Ploegh, Tom Kirchhausen, Bing Chen, Barton F Haynes, Frederick W. Alt. An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion. Science Immunology. (2022). DOI: 10.1126/sciimmunol.add5446.
    4. LijunWang, Xiuling You, Dengfeng Ruan, Rui Shao, Hai-Qiang Dai, Weiliang Shen, Guo-Liang Xu, Wanlu Liu, Weiguo Zou. TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. (2022) 13, 4709. https://doi.org/10.1038/s41467-022-32138-x.
    5. Yu Zhang, Xuefei Zhang, Hai-Qiang Dai, Hongli Hu, Frederick W. Alt. The role of chromatin loop extrusion in antibody diversification. Nature Reviews Immunology. (2022). https://doi.org/10.1038/s41577-022-00679-3.
    6. Hai-Qiang Dai#*, Hongli Hu#, Jiangman Lou, Adam Yongxin Ye, Zhaoqing Ba, Xuefei Zhang, Yiwen Zhang, Lijuan Zhao, Hye Suk Yoon, Aimee M. Chapdelaine-Williams, Nia Kyritsis, Huan Chen,Kerstin Johnson, Sherry Lin, Andrea Conte, Rafael Casellas, Cheng-Sheng Lee*, Frederick W. Alt*. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. (2021) 590, 338–343. 
      1. Recommended in Faculty Opinions.
    7. Hai-Qiang Dai#, Zhuoyi Liang#, Amelia N. Chang#, Aimee M. Chapdelaine-Williams, Beatriz Alvarado, Alex A. Pollen, Frederick W. Alt, Bjoern Schwer. Direct analysis of brain phenotypes via neural blastocyst complementation. Nature Protocols. (2020) 15 (10), 3154-3181.
    8. Zhaoqing Ba, Jiangman Lou, Adam Yongxin Ye, Hai-Qiang Dai, Edward W. Dring, Sherry G. Lin, Suvi Jain, Nia Kyritsis, Kyong-Rim Kieffer-Kwon, Rafael Casellas, Frederick W. Alt. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature. (2020) 586, 305–310.
    9. Hai-QiangDai#*, Hongli Hu#,JiangmanLou,Adam YongxinYe,Aimee M.Chapdelaine-Williams,NiaKyritsis,YiwenZhang,NicoleManfredonia,RachaelJudson,HuanChen,KerstinJohnson,SherryLin,ZhaoqingBa,AndreaConte,RafaelCasellas,Cheng-Sheng Lee*, Frederick W.Alt*. Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination. bioRxiv.(2020). https://doi.org/10.1101/2020.06.30.181222.
    10. Amelia N. Chang#, Zhuoyi Liang#, Hai-Qiang Dai#, Aimee M. Chapdelaine-Williams, Nick Andrews, Roderick T. Bronson, Bjoern Schwer, Frederick W. Alt. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. (2018) 563,126-130.
      1. Highlighted by Nature News & Views.
      2. Recommended in Faculty Opinions.
    11. Suvi Jain, Zhaoqing Ba, Yu Zhang, Hai-Qiang Dai, Frederick W. Alt. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. (2018) 174 (1),102-116.
    12. Hai-Qiang Dai#, Bang’an Wang#, Lu Yang#, Jiajia Chen#, Guochun Zhu, Meiling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun, Guoliang Xu. TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signaling. Nature. (2016) 538, 528-532.
      1. Top 10 Achievements of Chinese Sciences in 2016.
      2. Recommended in Faculty Opinions.
    13. Xiao Hu, Lei Zhang, Shiqing Mao, Zheng Li, Jiekai Chen, Runrui Zhang, Haiping Wu, Juan Gao, Fan Guo, Wei Liu, Guifang Xu, Hai-Qiang Dai, Yujiang Geno Shi, Xianlong Li, Boqiang Hu, Fuchou Tang, Duanqing Pei, Guoliang Xu. Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. Cell Stem Cell. (2014) 14, 512-522.