Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Yifan Wang,Caixuan Liu,Chao Zhang,Yanxing Wang,Qin Hong,Shiqi Xu,Zuyang Li,Yong Yang,Zhong Huang,Yao Cong,Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies,Nat Commun2022 Feb 15.
Xue Wang,Yuetong Wang,Zhaoyuan Fang,Hua Wang,Jian Zhang,Longfu Zhang,Hsinyi Huang,Zhonglin Jiang,Yujuan Jin,Xiangkun Han,Shenda Hou,Bin Zhou,Feilong Meng,Luonan Chen,Kwok-Kin Wong,Jinfeng Liu,Zhiqi Zhang,Xin Zhang,Haiquan Chen,Yihua Sun,Liang Hu,Hongbin Ji,Targeting HSPA1A in ARID2-deficient lung adenocarcinoma,Natl Sci Rev2021 Jan 30.
Xin Zheng,Jun Xiao,Qi Jiang,Lingming Zheng,Chang Liu,Chen Dong,Yuxiao Zheng,Peili Ni,Chi Zhang,Fang Zhang,Ruiyue Zhong,Huihua Ding,Qiong Wang,Ying Qiu,Minxia Gao,Jianping Ding,Nan Shen,Bin Wei,Hongyan Wang,AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus,EMBO J2022 Feb 22.
Tao Jiang,Pingyang Wang,Jie Zhang,Yanqiu Zhao,Jianying Zhou,Yun Fan,Yongqian Shu,Xiaoqing Liu,Helong Zhang,Jianxing He,Guanghui Gao,Xiaoqian Mu,Zhang Bao,Yanjun Xu,Renhua Guo,Hong Wang,Lin Deng,Ningqiang Ma,Yalei Zhang,Hui Feng,Sheng Yao,Jiarui Wu,Luonan Chen,Caicun Zhou,Shengxiang Ren,Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC: a multicenter phase-II trial,Signal Transduct Target Ther2021 Oct 15.
Huan Zhao,Kathy O.Lui,Bin Zhou,Pancreatic beta cell neogenesis: Debates and updates,Cell Metab2021 Nov 2.
Shiyang Chen,Yajuan Zheng,Xiaojuan Ran,Hui Du,Hua Feng,Lei Yang,Yating Wen,Changdong Lin,Shihui Wang,Mengwen Huang,Zhanjun Yan,Dianqing Wu,Hongyan Wang,Gaoxiang Ge,An Zeng,Yi Arial Zeng,Jianfeng Chen,Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling,Cell Res2021 Sep 13.
Shilin Yuan,Guanghong Liao,Menghuan Zhang,Yuanfei Zhu,Weidi Xiao,Kun Wang,Chuanyin Li,Caiwei Jia,Na Sun,Axel Walch,Daming Gao,Ping Xu,Qiang Deng,Jian Zhang,He Wang,Ronggui Hu,Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors against HBV,Cell Discov2021 Nov 2.
Hongdao Zhang,Fengjuan Zhang,Qinghua Chen,Mingzhe Li,Xiaolong Lv,Yali Xiao,Zhaozhen Zhang,Li Hou,Yana Lai,Ying Zhang,Aihua Zhang,Shiqi Gao,Heling Fu,Wen Xiao,Jianli Zhou,Feiyang Diao,Aimin Shi,Youqiang Su,Wentao Zeng,Ligang Wu,Jianmin Li,The piRNA pathway is essential for generating functional oocytes in golden hamsters,Nat Cell Biol2021 Sep 6.
Liang Xu,Peixue Li,Xue Hao,Yi Lu,Mingxian Liu,Wenqian Song,Lin Shan,Jiao Yu,Hongyu Ding,Shishuang Chen,Ailing Yang,Yi Arial Zeng, Lei Zhang,Hai Jiang,SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling,Protein Cell2020 Jul 13.
Peng Dai,Xin Wang,Lantao Gou,Zhitong Li,Ze Wen,Zonggui Chen,Minmin Hua,Ai Zhong,Lingbo Wang,Haiyang Su,Huida Wan,Kun Qian,Lujian Liao,Jinsong Li,Bin Tian,Dangsheng Li,Xiangdong Fu,Huijuan Shi,Yu Zhou,Mofang Liu,A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis,Cell2019 Dec 12
Luyu Fan,Liang Tan,Zhangcheng Chen,Jianzhong Qi,Fen Nie,Zhipu Luo,Jianjun Cheng,Sheng Wang,Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands,Nat Commun2020 Feb 24.
Xiaofeng Zhuo,Jian Wang,Jing Zhang，Leilei Jiang，Hongyu Hu,Junxia Lu,Solid-State NMR Reveals the Structural Transformation of the TDP-43 Amyloidogenic Region upon Fibrillation,J Am Chem Soc2020 Feb 7.
Jun Sun,Joerg Ermann,Ningning Niu,Guang Yan,Yang Yang,Yujiang Shi,Weiguo Zou,Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts,Bone Res2018 Apr 26
Fujiao Lv,Fei Qi,Zhi Zhang,Maorong Wen,Justin Kale,Alessandro Piai,Lingyu Du,Shuqing Wang,Liujuan Zhou,Yaqing Yang,Bin Wu,Zhijun Liu,Juan Del Rosario,Justin Pogmore,James J Chou,David W Andrews,Jialing Lin,Bo OuYang,An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane,EMBO J2021 Jun 8.
Bo Gao,Bo Jiang,Wenhui Xing,Zaiqi Xie,Zhuojing Luo,Weiguo Zou,Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration,Adv Sci2022 Feb 23.
Dongmei Cao,Jing Yu,Huan Wang,Zhipu Luo,Xinyu Liu,Licong He,Jianzhong Qi,Luyu Fan,Lingjie Tang,Zhangcheng Chen,Jinsong Li,Jianjun Cheng,Sheng Wang,Structure-based discovery of nonhallucinogenic psychedelic analogs,Science2022 Jan 27.
Siyang Wu,Ruixiu Cao,Bangbao Tao,Ping Wu,Chao Peng,Hong Gao,Ji Liang,Weiwei Yang,Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma,Adv Sci2022 Jan 20.
Yajuan Zhang, Ming Zhao, Hong Gao, Guanzhen Yu, Yun Zhao, Feng Yao, Weiwei Yang,MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion,Nat Metab2022 Mar 21.
Menghan Huang, Guixin Peng, Xueling Mao, Jintao Wang, Jingbo Zhou, Jianhui Zhang, Meirong Chen, Enduo Wang, Xiaolong Zhou,Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8,Nucleic Acids Res2022 Mar 31.
Maozhou Zhao, Dihang Lin, Heng Zuo, Huan Wei, Xin Wang, Lantao Gou, Mofang Liu,piRNA 3' uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells,Cell Res2022 Apr 15.

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