Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Man Jiang, Yu Li, Yiao Jiang, Runze Wang, Jiayin Peng, Yuang Wang, Zhen Qu, Yi Chang, Zhao Zhang, Yun Zhao,Hilnc- mediated UCP1 translation repression contributes to thermogenesis and energy expenditure,Theranostics.2026 Jan 1.
Xuefang Dong, Fangfang Xiong, Guangzhu Du, Yunfei Yang, Cheng Chen, Yun Cui, Xinlian Ding, Xiuling Li, Yidong Shen, Xinmiao Liang,A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration,Nat Commun.2026 Jan 28.
Jia-Xin Zhou, Zhen-Yu Shao, Lin Zhang, Jian-Nan Guo, Meng Wang, Qin Xu, Yi-Qin Wang, Qing Xu, Dan Zhou, Sheng-Xiang Ren, Yan-Hao Yu, Zhi-Hao Lu, Guo-Zheng Pang, Yao Cao, Yi-Lin Liu, Bin Zhou, Hong-Bin Ji, Yi-Han Chen, Hai-Ping Wu, Guo-Liang Xu, Liang Zhang & Ya-Rui Du,Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers,Nat Chem Biol.2026 Jan 22.
Qinhua Wu, Junxiang Ding, Ruikun He, Lijian Hui, Junwei Liu & Yixue Li,Exploring phenotype-related single-cells through attention-enhanced representation learning,Genome Med.2026 Jan 21.
Yajuan Zhang, Qizhen Fei, Yan Li, Siyao Wang, Tong Rong, Xueyuan Wu, Hong Gao, Chen Chen, Dong Gao, Yun Zhao, Guohui Li, Huiying Chu, Wenfeng Li & Weiwei Yang,An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression,Nat Commun.2026 Jan 21.
Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang, Yong Chen, Yanjing Li,WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity,Nat Commun.2026 Jan 21.
Huan Wang, Yunguang Li, Shijie Tang, Yikai Li, Yehan Zhang, Xiaoyi Yin, Juan He, Yiqin Zhu, Yi Zhang, Xiaohan Shi, Maoyuan Sun, Suizhi Gao, Bo Li, Lingyu Zhu, Shuai Yuan, Yaqi Pan, Meilong Shi, Penghao Li, Chuanqi Teng, Chaoliang Zhong, Xiaolu Yang, Zhendong Fu, Xinyu Liu, Xiaochao Kang, Yining Kang, Wenjie Li, Kailian Zheng, Bin Song, Wei Jing, Xiongfei Xu, Shiwei Guo, Luonan Chen, Dong Gao, Gang Jin,The vulnerabilities of chemotherapy resistant pancreatic cancer revealed by organoids of pre- and post- neoadjuvant therapy,Cancer Lett.2026 Jan 19.
Zile Fu, Yuanli Song, Fen Liu, Lv Chen, Shangli Cai, Peng Cui, Guoqiang Wang, Wenchuan Xie, Shu Zhang, Li Ding, Pei Wang, Bing Zhang, Henry Rodriguez, Feiling Feng, Xufeng Zhang, Wei Gong, Qiang Gao, Daming Gao, Hu Zhou, Jia Fan,Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer,Cancer Cell.2026 Jan 8.
Nana Chen, Mouxiang Fang, Leqi Zhong, Xiaolong Li, Yijia Zhou, Jianhua Zhan, Manli Wang, Zhaoyuan Fang, Hua Wang, Shijie Tang, Fang Liu, Bing Deng, Ning Chen, Jie Lei, Yuchen Zhang, Min Yan, Zhengzhi Zou, Yijun Gao, Chong Chen, Wenzhao Zhong, Srinivas Vinod Saladi, Hongbin Ji, Quentin Liu, Zifeng Wang, Bin He,KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition,Cell Death Differ.2026 Jan 8.
Chan Liu, Yifan Zhang, Yilun Wang, Min Wu, Yunchao Li, Jiashuai Wei, Jiawen Shi, Rong Wang, Li Su, Tingting Yang, Jin Li, Junjie Xiao, Jianping Ding, Tianlong Zhang,CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity,Mol Cell.2026 Jan 7.
Huafang Wei, Qianqian Song, Liying Wang, Qiong Deng, Bingbing Wu, Yinghong Chen, Tingting Han, Yueshuai Guo, Zuyang Li, Fucheng Dong, Shuang Ma, Qiaoyu Zhao, Xiangyi Shi, Chen Pan, Wanying Jiang, Xiaofei Liu, Yingyu Chen, Renjie Jiao, Li Yuan, Chao Liu, Xuejiang Guo, Yao Cong, Wei Li,PDCD5 promotes substrate release from the TRiC complex in cilia and flagella,Mol Cell.2026 Jan 7.
Bo Jiang, Wenhui Xing, Xiaocui Xu, Shuqin Chen, Heng Feng, Rui Shao, Jiatong Sun, Yazhuo Zhang, Zaiqi Xie, Wenxiang Wang, Xubin Yin, Yi Wang, Miaomiao Wang, Ling Li, Zhong Zhang, Bo Gao, Jinlong Suo, Xuye Hu, Lijun Wang, Jun Sun, Bin Zhou, Bo O. Zhou, Matthew B. Greenblatt, Rongrong Le & Weiguo Zou,Fibrous-layer resident Angptl7+ periosteal stem cells sense injury inflammation to orchestrate fracture repair,Cell Res.2026 Jan 8.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming-Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li,CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions,Adv Sci.2026 Jan 7.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng,CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human,Adv Sci.2025 Dec 21.
Meiting Yue, Zhen Qin, Shijie Tang, Xinlei Cai, Yikai Zhao, Chen Yang, Liang Chen, Luonan Chen, Hongbin Ji,Concurrent PIK3CA mutant promotes cachexia through inflammatory signaling in EGFR mutant lung cancer,Nat Commun.2025 Dec 16.
Bing Liu, Min Liu, Yajuan Zhang, Yifei Zhu, Dingpei Zhou, Hong Gao, Fan Yang, Dong Gao, Yun Zhao, BangBao Tao, Feng Yao, Weiwei Yang,Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis,Nat Commun.2025 Dec 14.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixing Wang, Maoping Chu, Bin Zhou, Chao Niu,Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury,Adv Sci.2025 Dec 3.
Yuanyong Huang, Yimei Sun, Hongyun Qi, Quanlong Jiang, Jialun Li, Mingzhi Chang, Xinyan Li, Lei Shu, Xiaoya Duan, Yiqin Wang, Kailun Fang, Hailei Mao, Mengmeng Han,A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization,Nature.2025 Oct. 15.
Zhini Zhu, Yaohui Li, Hao Xia, Chuanhui Yang, Zixuan Zhou, Yulin Chao, Qian Ba, Dianfan Li, Qianhui Qu,Molecular basis of prostaglandin E2 reuptake by organic anion transporter PGT,Nat Commun.2025 Dec 1.
Zhini Zhu, Yaohui Li, Hao Xia, Chuanhui Yang, Zixuan Zhou, Yulin Chao, Qian Ba, Dianfan Li, Qianhui Qu,Molecular basis of prostaglandin E2 reuptake by organic anion transporter PGT,Nat Commun.2025 Dec 1.

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