Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Jia Yu, Deyu Cai, Sha Zhao, Lei Wang, Xinlong Zheng, Anwen Xiong, Qi Wang, Bin Chen, Menghang Yang, Wei Li, Yan Wang, Jiajia Yuan, Changhong Zhao, Wei Shi, Caicun Zhou, Luonan Chen, Tao Jiang, Xiaohui Chen, Shengxiang Ren,Camrelizumab, an Anti-PD-1 Monoclonal Antibody, Plus Carboplatin and Nab-Paclitaxel as First-Line Setting for Extensive-Stage Small-Cell Lung Cancer: A Phase 2 Trial and Biomarker Analysis,MedComm.2025 Jul 27.
Kun Zhang, Xiang Yuan, Shuang Lu, Yajing Shu, Chenhua Wang, Jin Cen, Baihua Wu & Lijian Hui,Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation,Nat Protoc.2025 Jul 25.
Yu-Hang Pan, Lin Shan, Yu-Yao Zhang, Zheng-Hu Yang, Yuan Zhang, Shi-Meng Cao, Xiao-Qi Liu, Jun Zhang, Li Yang, Ling-Ling Chen,Pre-rRNA spatial distribution and functional organization of the nucleolus,Nature.2025 Jul 23.
Pianpian Lin, Yijun Qi, Huiying Chu, Hongyu Wu, Yajuan Zhang, Xiaolan Huang, Chen Li, Xiaoyan Xu, Hong Gao, Rong Zeng, Guohui Li, Weiwei Yang,PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate,Nat Commun.2025 Jul 22.
Qiaoling Zhu, Feng Yin, Jiachen Qin, Wanyu Shi, Yaojia Liu, Yuanyuan Zhao, Jianfang Wang, Lei Zhang, Aoyuan Fan, Dandan Cao, Qiqi Peng, Bin Zhou, Lijun Wang, Weiguo Zou, Rui Yue,Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration,Cell.2025 Jul 17.
Yuan-Yuan Zhang, Cai-Tao Li, You-Jia Zhou, Hao Li, Jing Li, Qing-Ping Xiong, Wei Zhou, Wenze Huang, Qiangfeng Cliff Zhang, Yangfei Xiang, En-Duo Wang, Beisi Xu, Ru-Juan Liu,A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification,Nat Commun.2025 Jul 4.
Na Liu, Bingxue Liu, Chun-Rui Ma, Zixin Cai, Jin-Tao Wang, Zi-Qing Chai, Nanlin Zhu, Ting Shao, Yue-Lei Chen, Yu Lin, Yirong Wang, Hong Xu, Xiao-Long Zhou,Mammalian tRNA acetylation determines translation efficiency and tRNA quality control,Nat Commun.2025 Jul 1.
Shanshan Ma, Luan Li, Zhixun Li, Shenjia Luo, Qi Liu, Wenjing Du, Benhua Qiu, Miao Gui, Xueliang Zhu & Qiang Guo,In situ cryo-electron tomography reveals the progressive biogenesis of basal bodies and cilia in mouse ependymal cells,Nat Commun.2025 Jul 1.
Dongyin He, Luyao Zhang, Leiye Yu, Yuhang Zhang, Jingjing Chen, Leibo Wang, Haoran Hu, Hongyu Liu, Hong Zheng, Jixin Xia, Jiahui Chen, Chenhui Li, Xin Li, Huiru Tang, Jia Liu, Ruobing Ren, Youhong Hu, Zhenfei Li,Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy,Proc Natl Acad Sci USA.2025 Jul 26.
Yudian Xiao, Bowen Wu, Qiuping Zhou, Fan Wu, Nei Li, Chenqi Xu, Xuexiang Han,Technologies for chimeric antigen receptor transgene delivery,Trends Mol Med.2025 Jun 19.
Chunman Zuo, Junjie Xia, Yupeng Xu, Ying Xu, Pingting Gao, Jing Zhang, Yan Wang & Luonan Chen,stClinic dissects clinically relevant niches by integrating spatial multi-slice multi-omics data in dynamic graphs,Nat Commun.2025 Jun 16.
Lin Lin, Carla Pou Casellas, Antonella F M Dost, Harry Begthel, Jeroen Korving, Stieneke van den Brink, Talya Dayton, Matthijs F M van Oosterhout, Niels Smakman, Lisa Thomann, Volker Thiel, Johan H van Es, Hans Clevers,Human airway submucosal gland organoids to study respiratory inflammation and infection,Cell Stem Cell.2025 Jun 10.
Zhimao Wu, Yingying Zhang, Juyuan Liu, Hao Liu, Jin Niu, Yan Li, Shanshan Xie, Xiumin Yan, Xueliang Zhu, Qing Wei,Ccdc13 is essential for the assembly of ciliary central microtubules,Natl Sci Rev.2025 Mar 17.
Zhiwen Liu, Xin Wan, Jiehui Chen, Yongjian Ma, Yonggao Fu, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang, Dahai Zhu, Jinsong Li, Naihe Jing, Xianfa Yang,Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo,Cell Discov.2025 Jun 3.
Xiao-Qi Liu, Pan Li, Bao-Qing Gao, Heng-Le Zhu, Liang-Zhong Yang, Yang Wang, Yu-Yao Zhang, Hao Wu, Yu-Hang Pan, Lin Shan, Hongtao Yu, Li Yang, Ling-Ling Chen,De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses,Cell.2025 May 27.
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J Mitchell, Xuexiang Han,Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components,Small Methods.2025 May 28.
Beibei Wang, Qiunan Jin, Hui Yang,Filament assembly powers NbaSPARDA in bacterial defense,Cell Res.2025 May 19.
Yi-Ming Zhao, Yan Jiang, Jin-Zhu Wang, Shang Cao, Hong Zhu, Wei-Kang Wang, Jian Yu, Jiaquan Liu, Jingyi Hui,GPATCH4 functions as a regulator of nucleolar R-loops in hepatocellular carcinoma cells,Nucleic Acids Res.2025 May 22.
A Katherine Hatstat, Rian Kormos, Vee Xu, Guoming Du, Lijun Liu, Shao-Qing Zhang, William F DeGrado,A Designed Zn2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases,J Am Chem Soc.2025 May 19.
Danyan Zhang, Ayiguzhali Abulitipu, Pengcheng Pang, Lei Bai, Lian Liu, Shaliyan Tuerxunmaimaiti, Wen Chen, Shuangfeng Chen, Houkun Lv, Yadong Fu, Qizhen Du, Fuquan Jin, Chunyan Yi, Yangmin Hao, Liyan Ma, Jinsong Li, Zhiyang Ling, Yaguang Zhang, Liang Zhao, Weiguo Fan, Guoli Du, Bing Sun,ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis,Hepatology.2025 May 15.

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