Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Chunman Zuo, Junjie Xia, Yupeng Xu, Ying Xu, Pingting Gao, Jing Zhang, Yan Wang & Luonan Chen,stClinic dissects clinically relevant niches by integrating spatial multi-slice multi-omics data in dynamic graphs,Nat Commun.2025 Jun 16.
Lin Lin, Carla Pou Casellas, Antonella F M Dost, Harry Begthel, Jeroen Korving, Stieneke van den Brink, Talya Dayton, Matthijs F M van Oosterhout, Niels Smakman, Lisa Thomann, Volker Thiel, Johan H van Es, Hans Clevers,Human airway submucosal gland organoids to study respiratory inflammation and infection,Cell Stem Cell.2025 Jun 10.
Zhimao Wu, Yingying Zhang, Juyuan Liu, Hao Liu, Jin Niu, Yan Li, Shanshan Xie, Xiumin Yan, Xueliang Zhu, Qing Wei,Ccdc13 is essential for the assembly of ciliary central microtubules,Natl Sci Rev.2025 Mar 17.
Zhiwen Liu, Xin Wan, Jiehui Chen, Yongjian Ma, Yonggao Fu, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang, Dahai Zhu, Jinsong Li, Naihe Jing, Xianfa Yang,Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo,Cell Discov.2025 Jun 3.
Xiao-Qi Liu, Pan Li, Bao-Qing Gao, Heng-Le Zhu, Liang-Zhong Yang, Yang Wang, Yu-Yao Zhang, Hao Wu, Yu-Hang Pan, Lin Shan, Hongtao Yu, Li Yang, Ling-Ling Chen,De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses,Cell.2025 May 27.
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J Mitchell, Xuexiang Han,Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components,Small Methods.2025 May 28.
Beibei Wang, Qiunan Jin, Hui Yang,Filament assembly powers NbaSPARDA in bacterial defense,Cell Res.2025 May 19.
Yi-Ming Zhao, Yan Jiang, Jin-Zhu Wang, Shang Cao, Hong Zhu, Wei-Kang Wang, Jian Yu, Jiaquan Liu, Jingyi Hui,GPATCH4 functions as a regulator of nucleolar R-loops in hepatocellular carcinoma cells,Nucleic Acids Res.2025 May 22.
A Katherine Hatstat, Rian Kormos, Vee Xu, Guoming Du, Lijun Liu, Shao-Qing Zhang, William F DeGrado,A Designed Zn2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases,J Am Chem Soc.2025 May 19.
Danyan Zhang, Ayiguzhali Abulitipu, Pengcheng Pang, Lei Bai, Lian Liu, Shaliyan Tuerxunmaimaiti, Wen Chen, Shuangfeng Chen, Houkun Lv, Yadong Fu, Qizhen Du, Fuquan Jin, Chunyan Yi, Yangmin Hao, Liyan Ma, Jinsong Li, Zhiyang Ling, Yaguang Zhang, Liang Zhao, Weiguo Fan, Guoli Du, Bing Sun,ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis,Hepatology.2025 May 15.
Tao Yang, Xiaohu Hu, Fei Cao, Fenglin Yun, Kaiwen Jia, Mingxiang Zhang, Gaohui Kong, Biyu Nie, Yuexing Liu, Haohao Zhang, Xiaoyu Li, Hongyan Gao, Jiantao Shi, Guanxiang Liang, Guohong Hu, Dennis L Kasper, Xinyang Song, Youcun Qian,Targeting symbionts by apolipoprotein L proteins modulates gut immunity,Nature.2025 May 14.
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu,CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis,Adv Sci (Weinh).2025 May 8.
Mingqi Jiao, Jiarui Li, Bingxu Zhong, Siyuan Du, Shuning Li, Manfei Zhang, Qibin Zhang, Zhongming Liang, Fan Liu, Chunman Zuo, Sijia Wang, Luonan Chen,De Novo Reconstruction of 3D Human Facial Images from DNA Sequence,Adv Sci (Weinh).2025 May 7.
Lijun Wang, Qian Ren, Shuqin Chen, Lixiang Lou, Xuye Hu, Wenhui Xing, Jinlong Suo, Jun Sun, Matthew B Greenblatt, Heng Feng, Weiguo Zou,Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway,Cell Rep.2025 Apr 24.
Jiacheng Guo, Ni Li, Qiuli Liu, Zongyao Hao, Guanghui Zhu, Xuege Wang, Hanling Wang, Qiang Pan, Beitao Xu, Ying Han, Guoying Zhang, Yannan Lian, Wei Zhang, Yongqiang Gu, Naiheng Lin, Xin Zeng, Zige Jin, Weihua Lan, Jun Jiang, Dong Gao, Liang Dong, Huairui Yuan, Chaozhao Liang, Jun Qin,KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy,Cancer Cell.2025 Apr 22.
Mengning Luo, Xinyang Song,Phyto-metabolites on guard: Role of gut microbial deglycosylation,Cell Host Microbe.2025 Apr 9.
Yurun Lu, Dan Liu, Zhongming Liang, Rui Liu, Pei Chen, Yitong Liu, Jiachen Li, Zhanying Feng, Lei M Li, Bin Sheng, Weiping Jia, Luonan Chen, Huating Li, Yong Wang,A pretrained transformer model for decoding individual glucose dynamics from continuous glucose monitoring data,Natl Sci Rev2025 Feb 8.
Shunrong Ji, Lihua Cao, Jing Gao, Yang Du, Zeng Ye, Xin Lou, Fen Liu, Yehan Zhang, Junfeng Xu, Xiaohan Shi, Huan Wang, Penghao Li, Yikai Li, Hongxu Chen, Zhicheng Yang, Suizhi Gao, Wuhu Zhang, Dan Huang, Shujuan Ni, Miaoyan Wei, Fei Wang, Yan Wang, Tian Ding, Desheng Jing, Guixiong Fan, Zhiyun Gong, Renquan Lu, Yi Qin, Jie Chen, Xiaowu Xu, Pei Wang, Bing Zhang, Li Ding, Ana I Robles, Henry Rodriguez, David K Chang, Ralph H Hruban, Dong Gao, Daming Gao, Gang Jin, Hu Zhou, Jianmin Wu, Xianjun Yu,Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups,Cancer Cell.2025 Apr 1.
Hengwei Jin, Zixin Liu, Jialing Mou, Muxue Tang, Xiuzhen Huang, Kuo Liu, Qianyu Zhang, Kathy O Lui, Bin Zhou,Dual genetic tracing demonstrates the heterogeneous differentiation and function of neuromesodermal progenitors in vivo,Proc Natl Acad Sci U S A.2025 Apr 8.
Xin Feng, Bo-Wen Jiang, Si-Nan Zhai, Chu-Xiao Liu, Hao Wu, Bang-Qi Zhu, Meng-Yuan Wei, Jia Wei, Li Yang, Ling-Ling Chen,Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models,Nat Biotechnol.2025 Mar 31.

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