Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Hua Li, Li Meng, Chun Chu, Changting Li, Haochen Yang, Kexin Cao, Yiming Zhu, Xue Gao, Chengsong Yan, Omer Dushek, Haopeng Wang, Xiaoshan Shi, Chenqi Xu,Lipid-regulated phosphorylation hierarchy of the T cell receptor tyrosine motifs,Mol Cell.2025 Oct 2.
Xinyan Zhang, Luonan Chen,Quantifying interventional causality by knockoff operation,Adv Sci.2025 Oct 3.
Hui Chen, Zhicong Liu, Qiang Shu, Bin Zhou,Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications,Adv Sci.2025 Sep 29.
Jinlong Suo, Ling Li, Wuyuan Tan, Xubin Yin, Jinghui Wang, Rui Shao, Shaokun Sun, Si-Kun Guo, Jingyi Feng, Bao-Qing Gao, Ying Wang, Meng-Yuan Wei, Lijun Wang, Heng Feng, Xiang Gao, Ping Hu, Xianyou Zheng, Ling-Ling Chen, Guanghua Lei, Youkui Huang, Weiguo Zou,Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice,Nat Commun.2025 Sep 26.
Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu, Ding Song, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huanwei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng, Hai Jiang,A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2,Nat Biotechnol.2025 Sep 10.
Xiao-Peng Han, Ming Rao, Yu Chang, Jun-Yan Zhu, Jun Cheng, Yu-Ting Li, Wu Qiong, Si-Chao Ye, Qiurong Zhang, Shao-Qing Zhang, Ling-Ling Chen, Fajian Hou, Jin Zhong, Jiaquan Liu,ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly,Cell Res.2025 Sep 19.
Rui Gao, Chang Xu, Chen Liu, Zhenyan Zhu, Min Wang, Xueyan Wei, Peng Ning, Wei Zhang, Yingze Li, Yajuan Zhang, Junwu Shen, Yifan Tong, Feng Tao, Xiaolei Chen, Xiaoyi Jiang, Huan Ren, Cheng Lv, Gustavo R Plaza, Jason Miska, Haiming Fan, Xiaoqing Zhang, Yichao Tang, Yalei Dai, Weiwei Yang, Bin He, Yu Cheng,An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano-Immunotherapy,Adv Mater.2025 Sep 13.
Jun Lu, Minjuan Hu, Yikai Zhao, Tianqing Chu, Wei Zhang, Yijia Zhou, Xinlei Cai, Jun Wu, Liang Hu, Chunlei Shi, Liwen Xiong, Aiqin Gu, Huimin Wang, Yanwei Zhang, Yuqing Lou, Runbo Zhong, Zhiqiang Gao, Hongyu Liu, Chao Zhou, Yingli Wu, Liang Zhu, Hua Zhong, Hongbin Ji, Baohui Han,Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer,Signal Transduct Target Ther.2025 Sep 12.
Zhengxu Ren, Chenqi Xu,Touch of youth: Mechanosensing expands stem-like CAR-T cells,Immunity.2025 Sep 9.
Jiangshan Cong, Qing Li, Yangyang Li, Minghao Li, Yan Shi, Peiran Hu, Xidi Yin, Qianyun Zhang, Jianzhong Sheng, Jinsong Li, Guolian Ding, Yu Zhang, Hefeng Huang,Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference,Cell Discov.2025 Sep 9.
Yawei Song, Zilv Mei, Qijie Zheng, Qingqing Yuan, Yu Liang, Jiaqi Gao, Lang Zhou, Shuheng Wu, Wei Wu,Benchmarking Ploidy Estimation Methods for Bulk and Single-Cell Whole Genome Sequencing,Adv Sci (Weinh).2025 Sep 8.
Kaile Wang, Rui Ye, Shanshan Bai, Zhenna Xiao, Lei Yang, Jianzhuo Li, Chenling Tang, Emi Sei, Jinyu Peng, Anna K Casasent, Steven H Lin, Chandandeep Nagi, Alastair M Thompson, Savitri Krishnamurthy, Nicholas E Navin,Coalescing single-cell genomes and transcriptomes to decode breast cancer progression,Cell.2025 Aug 26.
Maoying Han, Zhicong Liu, Lei Liu, Zhixin Kang, Xiuzhen Huang, Nicola Smart, Xuekun Li, Qiang Shu, Bin Zhou,Spatio-Temporal Proliferative Heterogeneity of Intra-Organ Endothelial Cells,Circ Res.2025 Aug 15.
Runyang Feng, Zheyan Fang, Shuang Zhao, You-en Zhang, Na Wu, Zhenyang Guo, Xin Zhong, Bixuan Jiang, Hongfei Xu, Hangnan Hong, Zhentao Zhang, Mukaddas Abdurahman, Xueting Yu, Jilong Geng, Xiansu Nie, Supuya Abuduwahapi, Dong Huang, Gang Zhao, Wenbin Zhang, Hao Lu, Li Shen, Xin Zhao, Zhaoyang Chen, Junjie Guo, Hongchao Zheng, Yue He, Sanwu Wu, Jiayin Peng, Jiawen Song, Xiao Wang, Haomin Li, Yuli Huang, Shengying Qin, Haojie Lu, Xiangdong Wang, Jianguo Zhao, Lei Huang, Yun Zhao, Peng Li, Junbo Ge, Hua Li,SIRT6 Lysine-Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE-Cadherin Pathway Regulating Vascular Endothelial Barrier,Adv Sci.2025 Aug 14.
Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu, Yurun Lu, Yehan Zhang, Shiwei Guo, Juan He, Yikai Li, Yi Zhang, Xiaohan Shi, Yuanxiang Miao, Chaoliang Zhong, Yiqin Zhu, Yi Ju, Yuejia Liu, Maoyuan Sun, Yong Wang, Luonan Chen, Hu Zhou, Gang Jin, Dong Gao,A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy,Cell Stem Cell.2025 Aug 13.
Yuzhu Zhang, Changping Yin, Yimin Wang, Kunming Yan, Bo Zhao, Xin Hu, Youzhong Wan, Hong Cheng, Jing Huang,A common structural mechanism for RNA recognition by the SF3B complex in mRNA splicing and export,Nucleic Acids Res.2025 Aug 11.
Jia Yu, Deyu Cai, Sha Zhao, Lei Wang, Xinlong Zheng, Anwen Xiong, Qi Wang, Bin Chen, Menghang Yang, Wei Li, Yan Wang, Jiajia Yuan, Changhong Zhao, Wei Shi, Caicun Zhou, Luonan Chen, Tao Jiang, Xiaohui Chen, Shengxiang Ren,Camrelizumab, an Anti-PD-1 Monoclonal Antibody, Plus Carboplatin and Nab-Paclitaxel as First-Line Setting for Extensive-Stage Small-Cell Lung Cancer: A Phase 2 Trial and Biomarker Analysis,MedComm.2025 Jul 27.
Kun Zhang, Xiang Yuan, Shuang Lu, Yajing Shu, Chenhua Wang, Jin Cen, Baihua Wu & Lijian Hui,Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation,Nat Protoc.2025 Jul 25.
Yu-Hang Pan, Lin Shan, Yu-Yao Zhang, Zheng-Hu Yang, Yuan Zhang, Shi-Meng Cao, Xiao-Qi Liu, Jun Zhang, Li Yang, Ling-Ling Chen,Pre-rRNA spatial distribution and functional organization of the nucleolus,Nature.2025 Jul 23.
Pianpian Lin, Yijun Qi, Huiying Chu, Hongyu Wu, Yajuan Zhang, Xiaolan Huang, Chen Li, Xiaoyan Xu, Hong Gao, Rong Zeng, Guohui Li, Weiwei Yang,PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate,Nat Commun.2025 Jul 22.

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