Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Yi Ni Luo, Yazi Deng, Yu Liang, Wei Wu, Wei Wu, Lu Wang,A de novo H3.2K9me2 deposition pathway establishes heterochromatin for suppressing transposon mobilization during fly somatic development,Nucleic Acids Res.2026 Feb 24.
Youkui Huang, Yao-Qi Chen, Si-Yu Lou, Xiang Gao, Yu-Xin Liu, Yu-Lu Zhang, Fang Nan, Ling-Ling Chen, Li Yang,IRES-cargo interplay structurally modulates circular RNA translation,Cell Res.2026 Feb 26.
Huanhuan Feng, Zhixue Li, Hongdao Zhang, Yuli Zheng, Beiying Xu, Yao Zhang, Lin Zou, Ligang Wu,Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells,Nucleic Acids Res.2026 Feb 5.
Yuanhao Wang, Yuhan Wang, Wenjie Yuan, Mingyu Fan, Xiaojing Wang, Anhui Wang, Yanling Bao, Yajing Zhang, Jia Chi Tan, Jianglai Wang, Junshuang Liu, Tianqi Huang, Zixuan Han, Biling Pei, Lijuan Chen, Zhengxu Ren, Xueqing Wang, Lanxin Hu, Siqi Wu, Mengke Pang, Sifan Wang, Zihuan Yang, Jiaze Li, Delian Huang, Shuai Shao, Huairui Yuan, Ling Wu, Yinnian Feng, Penghui Zhou, Guohui Li, Bo Sun, Chenqi Xu, Nicholas R J Gascoigne, Xiang Zhao,Tuning the sensitivity of mechanosensory receptors through histidine scanning,Cell.2026 Feb 18.
Huan Zhao, Hui Chen, Zhixin Kang, Xiuzhen Huang, Jingting Zhu, Zixin Liu, Xiuxiu Liu, Ximeng Han, Jie Lu, Bin Zhou,Genetic recording of pancreatic beta cell proliferation,Proc Natl Acad Sci U.S.A.2026 Feb 17.
Yinghua Wang, Weiwei Hu, Rui Xia, Xianfa Yang, Yange Gu, Zihan Ning, Tiange Yang, Chune Yu, Lulu Zhang, Dun Li, Yitian Jin, Jianhua Li, Feifei Zhang, Yaochen Xu, Chenqi Xu, Zhengxin Wang, Naihe Jing, Luonan Chen, Guangchuan Wang,CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response,Cell.2026 Feb 11.
Liucheng Li, Jianwei You, Zi-Qing Chai, Xueshan Li, Xinlei Cai, Lin Wang, Fang Yang, Lingzhi Zhu, Wen Mi, Xinyi Xia, Haohang Yan, Fei Li, Juan Wang, Tong-Jin Zhao, Ligong Chen, Hongbin Ji, Pingyu Liu, Xiao-Long Zhou, Li Chen & Fuming Li,SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth,Nat Metab.2026 Feb 6.
Dongyin He, Haoran Hu, Kai Xiao, Yuhang Zhang, Yongbing Cheng, Shaozhuo Jiao, Yimei Hao, Yuanyuan Cai, Ziqun Liu, Xinran Yan, Qinsheng Chen, Xiyan Mu, Qi Wang, Shan Peng, Guoqin Sang, Xiaoling Zhi, Yanxia Chang, Qing Ye, Yuyao Yang, Meixia Che, Shengsong Huang, Hongqian Guo, Luonan Chen, Huiru Tang, Xuefeng Qiu, Zhenfei Li,Analysis of the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins using snFLARE-seq and mxFRIZNGRND,Nat Commun.2026 Feb 7.
Wen Xiao, Yuli Zheng, Hongdao Zhang, Beiying Xu, Ruiwen Zhang, Ligang Wu,An absolute quantification atlas of small non-coding RNAs across diverse mammalian tissues and cell lines,Nat Commun.2026 Feb 3.
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang,Single-Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems,Adv Sci.2026 Feb 3.
Yingze Li, Mengge Zheng, Zhenyan Zhu, Yajuan Zhang, Peng Ning, Haotian Chen, Rui Gao, Chang Xu, Xueyan Wei, Yali Liu, Yingying Wang, Ruimei Zhou, Yuan Li, Zhenguang Li, Cheng Lv, Chen Liu, Junfang Xu, Zihan Guo, Zhixiang Hu 1 2 3 4, Lan Fang 9, Ke Wei 10, Mengying Feng 10, Changshi Zhou 11 12, Yunlang She 1, Weiyan Sun 1, Erzhen Chen, Gustavo R Plaza, Bin He, Jason Miska, Weiwei Yang, Yichao Tang, Haipeng Liu, Chang Chen, Yu Cheng,Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity,Cell Res.2026 Feb 3.
Man Jiang, Yu Li, Yiao Jiang, Runze Wang, Jiayin Peng, Yuang Wang, Zhen Qu, Yi Chang, Zhao Zhang, Yun Zhao,Hilnc- mediated UCP1 translation repression contributes to thermogenesis and energy expenditure,Theranostics.2026 Jan 1.
Xuefang Dong, Fangfang Xiong, Guangzhu Du, Yunfei Yang, Cheng Chen, Yun Cui, Xinlian Ding, Xiuling Li, Yidong Shen, Xinmiao Liang,A versatile platform for sequential glyco-, phospho-, and proteomics with multi-PTMs integration,Nat Commun.2026 Jan 28.
Jia-Xin Zhou, Zhen-Yu Shao, Lin Zhang, Jian-Nan Guo, Meng Wang, Qin Xu, Yi-Qin Wang, Qing Xu, Dan Zhou, Sheng-Xiang Ren, Yan-Hao Yu, Zhi-Hao Lu, Guo-Zheng Pang, Yao Cao, Yi-Lin Liu, Bin Zhou, Hong-Bin Ji, Yi-Han Chen, Hai-Ping Wu, Guo-Liang Xu, Liang Zhang & Ya-Rui Du,Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers,Nat Chem Biol.2026 Jan 22.
Qinhua Wu, Junxiang Ding, Ruikun He, Lijian Hui, Junwei Liu & Yixue Li,Exploring phenotype-related single-cells through attention-enhanced representation learning,Genome Med.2026 Jan 21.
Yajuan Zhang, Qizhen Fei, Yan Li, Siyao Wang, Tong Rong, Xueyuan Wu, Hong Gao, Chen Chen, Dong Gao, Yun Zhao, Guohui Li, Huiying Chu, Wenfeng Li & Weiwei Yang,An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression,Nat Commun.2026 Jan 21.
Duo Wang, Xianle Shi, Jiaying Xie, Lijie Zhao, Bin Wu, Qiman Dong, Yaoguang Huang, Jinlong Suo, Xinyu Wang, Beixuan He, Shukun Yan, Hongjuan Xue, Yuheng Shi, Yingbin Liu, Jianlong Wang, Yong Chen, Yanjing Li,WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity,Nat Commun.2026 Jan 21.
Huan Wang, Yunguang Li, Shijie Tang, Yikai Li, Yehan Zhang, Xiaoyi Yin, Juan He, Yiqin Zhu, Yi Zhang, Xiaohan Shi, Maoyuan Sun, Suizhi Gao, Bo Li, Lingyu Zhu, Shuai Yuan, Yaqi Pan, Meilong Shi, Penghao Li, Chuanqi Teng, Chaoliang Zhong, Xiaolu Yang, Zhendong Fu, Xinyu Liu, Xiaochao Kang, Yining Kang, Wenjie Li, Kailian Zheng, Bin Song, Wei Jing, Xiongfei Xu, Shiwei Guo, Luonan Chen, Dong Gao, Gang Jin,The vulnerabilities of chemotherapy resistant pancreatic cancer revealed by organoids of pre- and post- neoadjuvant therapy,Cancer Lett.2026 Jan 19.
Zile Fu, Yuanli Song, Fen Liu, Lv Chen, Shangli Cai, Peng Cui, Guoqiang Wang, Wenchuan Xie, Shu Zhang, Li Ding, Pei Wang, Bing Zhang, Henry Rodriguez, Feiling Feng, Xufeng Zhang, Wei Gong, Qiang Gao, Daming Gao, Hu Zhou, Jia Fan,Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer,Cancer Cell.2026 Jan 8.
Nana Chen, Mouxiang Fang, Leqi Zhong, Xiaolong Li, Yijia Zhou, Jianhua Zhan, Manli Wang, Zhaoyuan Fang, Hua Wang, Shijie Tang, Fang Liu, Bing Deng, Ning Chen, Jie Lei, Yuchen Zhang, Min Yan, Zhengzhi Zou, Yijun Gao, Chong Chen, Wenzhao Zhong, Srinivas Vinod Saladi, Hongbin Ji, Quentin Liu, Zifeng Wang, Bin He,KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition,Cell Death Differ.2026 Jan 8.

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