Representative Publications----Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS

Research

Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang,MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury,Cell Discov.2025 Feb 18.
Meng Yan, Xiaoyu Merlin Zhang, Zhenhua Yang, Miao Jia, Rongyu Liao, Jinsong Li,Visualization of chromosomal reorganization induced by heterologous fusions in the mammalian nucleus,Nat Commun.2025 Feb 10.
Ximeng Han, Yi Li, Enci Wang, Huan Zhu, Xiuzhen Huang, Wenjuan Pu, Mingjun Zhang, Kuo Liu, Huan Zhao, Zixin Liu, Yufei Zhao, Linghong Shen, Yan Li, Xiao Yang, Qing-Dong Wang, Xin Ma, Ruling Shen, Kathy Lui, Lixin Wang, Ben He, Bin Zhou,Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics,Circulation.2025 Feb 10.
Xiaojing Gao, Yuanyuan Yin, Yiqian Chen, Ling Lu, Jian Zhao, Xu Lin, Jiarui Wu, Qingrun Li, Rong Zeng,Uncovering dark mass in population proteomics: Pan-analysis of single amino acid polymorphism relevant to cognition and aging,Cell Genom.2025 Jan 26.
Shan-Shan Wang, Jia Yuan, Xinyu Thomas Tang, Xiujuan Yin, Ke Fang, Lin Veronica Chen, Zhenggang Ren, Bo O Zhou,Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis,J Exp Med.2025 Jan 31.
Yulin Chao, Zixuan Zhou, Hao Xia, Chuanhui Yang, Tingting Li , Yi-Quan Tang, Yilai Shu, Qian Ba, Jiaxu Hong, Dianfan Li, Qianhui Qu,Transport and inhibition mechanism for human TauT-mediated taurine uptake,Cell Res.2025 Jan 21.
Hao Wu, Chu-Xiao Liu, Ling-Ling Chen,Beyond housekeeping: a new role of snoRNA in nascent protein secretion,Cell Res.2025 Jan 20.
Yongjian Ma, Meng Yan, Zhenfei Xie, Hongling Zhang, Zhoujie Li, Yuanyuan Li, Suming Yang, Meiling Zhang, Wen Li & Jinsong Li,Generation of live mice from haploid ESCs with germline-DMR deletions or switch,Cell Discov.2025 Jan 21.
Qi Xiong, Zhini Zhu, Tingting Li, Xiaotian Li, Zixuan Zhou, Yulin Chao, Chuanhui Yang, Suihan Feng, Qianhui Qu & Dianfan Li,Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling,Nat Struct Mol Biol.2025 Jan 17.
Feifei Zhang, Ryan D. Chow, Emily He, Chuanpeng Dong, Shan Xin, Daniyal Mirza, Yanzhi Feng, Xiaolong Tian, Nipun Verma, Medha Majety, Yueqi Zhang, Guangchuan Wang & Sidi Chen,Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy,Nat Biotechnol.2025 Jan 16.
Yanpu Wu, Xinyan Zhang, Liang Sun, Qingqing Wu, Xiaoping Liu, Yueyi Deng, Zhenzhen Lu, Zhongxia Li, Chaoming Deng, Ruikun He, Luyun Zhang, Rong Zeng, Xuguang Zhang, Luonan Chen, Xu Lin,Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study,Natl Sci Rev.2024 Nov 26.
Pengyu Fan, Xue-Ying Shang, Aixia Song, Shuo Chen, Run-Yuan Mao, Jingchuan Ma, Jiwei Chen, Zhenning Wang, Hai Zheng, Bolin Tao, Lei Hong, Jiaxian Liu, Wei Xu, Wei Jiang, Hongjie Shen, Qi Zhang, Huijuan Yang, Xiao-Ming Meng, Fei Lan, Jingdong Cheng, Congling Xu, Peng Zhang, Hai Jiang & Fei Xavier Chen,Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition,Nat Chem Biol.2025 Jan 14.
Qian Ren, Wenhui Xing, Bo Jiang, Heng Feng, Xuye Hu, Jinlong Suo, Lijun Wang & Weiguo Zou,Tenascin-C promotes bone regeneration via inflammatory macrophages,Cell Death Differ.2025 Jan 10.
Fei Li, Pengfei Dai, Huili Shi, Yajuan Zhang, Juan He, Anuradha Gopalan, Dan Li, Yu Chen, Yarui Du, Guoliang Xu, Weiwei Yang, Chao Liang & Dong Gao,LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer,Cell Res.2025 Jan 2.
Xianle Shi, Yanjing Li, Hongwei Zhou, Xiukun Hou, Jihong Yang, Vikas Malik, Francesco Faiola, Junjun Ding, Xichen Bao, Miha Modic, Weiyu Zhang, Lingyi Chen, Syed Raza Mahmood, Effie Apostolou, Feng-Chun Yang, Mingjiang Xu, Wei Xie, Xin Huang, Yong Chen & Jianlong Wang,DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells,Nat Commun.2024 Dec 30.
Hua Wang, Shijie Tang, Qibiao Wu, Yayi He, Weikang Zhu, Xinyun Xie, Zhen Qin, Xue Wang, Shiyu Zhou, Shun Yao, Xiaoling Xu, Chenchen Guo, Xinyuan Tong, Shuo Han, Yueh-Hung Chou, Yong Wang, Kwok-Kin Wong, Cai-Guang Yang, Luonan Chen, Liang Hu, Hongbin Ji,Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target,Natl Sci Rev.2024 Nov 7.
Hongxin Li, Shaohua Zhang, Xiuzhen Huang, Zhenqian Zhang, Kuo Liu, Qing-Dong Wang, Alex F. Chen, Kathy O. Lui, Kun Sun & Bin Zhou,Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis,Cell Discov.2024 Dec 3.
Lequn Wang, Xiaosheng Bai, Chuanchao Zhang, Qianqian Shi, Luonan Chen,Spatially Aware Domain Adaptation Enables Cell Type Deconvolution from Multi-Modal Spatially Resolved Transcriptomics,Small Methods.2024 Dec 2.
Guanchao Wang, Tiantian Lu, Lei Zhang & Jianping Ding,IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation,Nat Commun.2024 Nov 30.
Xinyi Xu, Haotian Chen, Zhengxu Ren, Xiaomin Xu, Wei Wu, Haochen Yang, JinJiao Wang, Yumeng Zhang, Qiuping Zhou, Hua Li, Shaoqing Zhang, Haopeng Wang, Chenqi Xu,Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity,Immunity.2024 Nov 27.

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